On June 6, 2026, Tom Dayspring co-authored a landmark article with Michael Rae and Peter Attia titled "The beginning of the end of". This high-profile publication coincides with Dayspring's return to the airwaves to untangle the knotty relationship between cardiovascular lipids and brain health. On The Peter Attia Drive, host Peter Attia introduced his long-time collaborator as "one of the most thoughtful lipidologists I know," praising his "remarkable ability to take complex physiology and make it not only clinically relevant but understandable."
The episode quickly dives into the weeds of brain lipidology, where Tom Dayspring challenges conventional thinking about cholesterol levels. Explaining how a drop in LDL doesn't signal a failure of reverse transport, Dayspring noted that "if LDL cholesterol goes down, if you really even look at your total cholesterol, it, it's gonna go down too," pointing out that cells simply maintain their own "cholesterol balance."
Even for a seasoned clinician like Peter Attia, the intricate mechanics of these cellular pathways can be dizzying. Attia pushed back during a technical breakdown of liver receptors, admitting, "So Tom, I'm, I'm actually quite confused by this." He pressed Tom Dayspring to explain how that LDL interacts with the LDL receptor and what enables the key to fit into the lock.
As Tom Dayspring and Peter Attia continue to bridge the gap between cardiovascular lipidology and neurodegenerative disease prevention, their collaborative work is set to redefine how clinicians approach APOE and Alzheimer's risk. Expect their latest joint article to spark a broader debate over whether aggressive lipid-lowering therapies are the ultimate key to cognitive longevity.